| Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection Y Aoki, D Röshammar, B Hamrén, AC Hooker Journal of pharmacokinetics and pharmacodynamics 44, 581-597, 2017 | 37 | 2017 |
| Cluster Newton method for sampling multiple solutions of underdetermined inverse problems: application to a parameter identification problem in pharmacokinetics Y Aoki, K Hayami, HD Sterck, A Konagaya SIAM Journal on Scientific Computing 36 (1), B14-B44, 2014 | 32 | 2014 |
| Preconditioning of nonlinear mixed effects models for stabilisation of variance-covariance matrix computations Y Aoki, R Nordgren, AC Hooker The AAPS journal 18, 505-518, 2016 | 21 | 2016 |
| Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs T Mochizuki, Y Aoki, T Yoshikado, K Yoshida, Y Lai, H Hirabayashi, ... Clinical and Translational Science 15 (6), 1519-1531, 2022 | 16 | 2022 |
| Cluster Gauss–Newton method: an algorithm for finding multiple approximate minimisers of nonlinear least squares problems with applications to parameter estimation of … Y Aoki, K Hayami, K Toshimoto, Y Sugiyama Optimization and Engineering, 1-31, 2020 | 16 | 2020 |
| PopED lite: an optimal design software for preclinical pharmacokinetic and pharmacodynamic studies Y Aoki, M Sundqvist, AC Hooker, P Gennemark Computer methods and programs in biomedicine 127, 126-143, 2016 | 13 | 2016 |
| Improvements to the cluster Newton method for underdetermined inverse problems P Gaudreau, K Hayami, Y Aoki, H Safouhi, A Konagaya Journal of computational and applied mathematics 283, 122-141, 2015 | 11 | 2015 |
| Cluster Newton Method for Sampling Multiple. Solutions of an Underdetermined Inverse Problem: Parameter Identification for Pharmacokinetics Y Aoki, K Hayami, HD Sterc, A Konagaya SIAM Journal on Scientific Computing (accepted for publication)(Preliminary …, 2011 | 11 | 2011 |
| Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies T Yoshikado, Y Aoki, T Mochizuki, AD Rodrigues, K Chiba, H Kusuhara, ... CPT: Pharmacometrics & Systems Pharmacology 11 (10), 1341-1357, 2022 | 10 | 2022 |
| Revisiting nonlinear Bosentan pharmacokinetics by physiologically based pharmacokinetic modeling: target binding, albeit not a major contributor to nonlinearity, can offer … S Koyama, K Toshimoto, W Lee, Y Aoki, Y Sugiyama Drug Metabolism and Disposition 49 (4), 298-304, 2021 | 9 | 2021 |
| Assessing reproducibility and utility of clustering of patients with type 2 diabetes and established CV disease (SAVOR-TIMI 53 trial) Y Aoki, B Hamrén, LE Clegg, C Stahre, DL Bhatt, I Raz, BM Scirica, ... PLoS One 16 (11), e0259372, 2021 | 7 | 2021 |
| Cross-species translation of biophase half-life and potency of GalNAc-conjugated siRNAs A Boianelli, Y Aoki, M Ivanov, A Dahlén, P Gennemark nucleic acid therapeutics 32 (6), 507-512, 2022 | 6 | 2022 |
| Averaged Model Based Decision Making for Dose Selection Studies Y Aoki, B Hamrén, D Röshammar, AC Hooker Annual Meeting of the Population Approach Group in Europe, 2014 | 5 | 2014 |
| Predicting In Vivo Target Occupancy (TO) Profiles via Physiologically Based Pharmacokinetic–TO Modeling of Warfarin Pharmacokinetics in Blood: Importance of Low Dose Data and … W Lee, MS Kim, J Kim, Y Aoki, Y Sugiyama Drug Metabolism and Disposition 51 (9), 1145-1156, 2023 | 4 | 2023 |
| Predicting in vivo target occupancy (TO) profiles via PBPK-TO modeling of warfarin pharmacokinetics in blood: importance of low dose data and prediction of stereoselective … W Lee, MS Kim, J Kim, Y Aoki, Y Sugiyama Drug Metabolism and Disposition, 2023 | 4 | 2023 |
| Saddle-reset for robust parameter estimation and identifiability analysis of nonlinear mixed effects models H Bjugård Nyberg, AC Hooker, RJ Bauer, Y Aoki The AAPS Journal 22, 1-11, 2020 | 4 | 2020 |
| Study of singular capillary surfaces and development of the cluster Newton method Y Aoki University of Waterloo, 2012 | 4 | 2012 |
| Bilirubin levels and kidney function decline: An analysis of clinical trial and real world data Y Aoki, CS Cabrera, M Ouwens, K Bamberg, J Nyström, I Raz, BM Scirica, ... Plos one 17 (6), e0269970, 2022 | 3 | 2022 |
| Bounded and unbounded capillary surfaces in a cusp domain Y Aoki, D Siegel Pacific Journal of Mathematics 257 (1), 143-165, 2012 | 3 | 2012 |
| Analysis of asymptotic solutions for cusp problems in capillarity Y Aoki University of Waterloo, 2007 | 3 | 2007 |
Ken HayamiProfessor, National Institute of Informatics, TokyoVerified email at nii.ac.jp
