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David R Powell, MD
David R Powell, MD
Consultant, Lexicon Pharmaceuticals, Inc.
lexpharma.com의 이메일 확인됨
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Direct control of the Forkhead transcription factor AFX by protein kinase B
GJPL Kops, ND Ruiter, AMM De Vries-Smits, DR Powell, JL Bos, ...
Nature 398 (6728), 630-634, 1999
13951999
Insulin-like growth factor binding protein-1: recent findings and new directions
PDK Lee, LC Giudice, CA Conover, DR Powell
Proceedings of the Society for Experimental Biology and Medicine 216 (3 …, 1997
6221997
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression
W Zhang, S Patil, B Chauhan, S Guo, DR Powell, J Le, A Klotsas, ...
Journal of Biological Chemistry 281 (15), 10105-10117, 2006
6192006
Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN
DB Donoviel, DD Freed, H Vogel, DG Potter, E Hawkins, JP Barrish, ...
Molecular and cellular biology 21 (14), 4829-4836, 2001
5502001
Regulation and function of insulin-like growth factor-binding protein-1
PDK Lee, CA Conover, DR Powell
Proceedings of the Society for Experimental Biology and Medicine 204 (1), 4-29, 1993
5071993
Lrp5 functions in bone to regulate bone mass
Y Cui, PJ Niziolek, BT MacDonald, CR Zylstra, N Alenina, DR Robinson, ...
Nature medicine 17 (6), 684-691, 2011
4872011
Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-α regulate transcriptional signaling and apoptosis
B Liu, HY Lee, SA Weinzimer, DR Powell, JL Clifford, JM Kurie, P Cohen
Journal of Biological Chemistry 275 (43), 33607-33613, 2000
4052000
Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia
T Rieg, T Masuda, M Gerasimova, E Mayoux, K Platt, DR Powell, ...
American Journal of Physiology-Renal Physiology 306 (2), F188-F193, 2014
3002014
Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia
SI Tazuke, NM Mazure, J Sugawara, G Carland, GH Faessen, LF Suen, ...
Proceedings of the National Academy of Sciences 95 (17), 10188-10193, 1998
2881998
Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain …
YL Lee, RL Hintz, PM James, PDK Lee, JE Shively, DR Powell
Molecular Endocrinology 2 (5), 404-411, 1988
2831988
Hepatic nuclear factor 3-and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes
RM O'Brien, EL Noisin, A Suwanichkul, T Yamasaki, PC Lucas, JC Wang, ...
Molecular and cellular biology 15 (3), 1747-1758, 1995
2761995
LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo‐controlled trial
B Zambrowicz, J Freiman, PM Brown, KS Frazier, A Turnage, J Bronner, ...
Clinical Pharmacology & Therapeutics 92 (2), 158-169, 2012
2662012
Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1.
DR Powell, A Suwanichkul, ML Cubbage, LA DePaolis, MB Snuggs, ...
Journal of Biological Chemistry 266 (28), 18868-18876, 1991
2661991
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion
LD Pound, SA Sarkar, RKP Benninger, Y Wang, A Suwanichkul, ...
Biochemical Journal 421 (3), 371-376, 2009
2182009
Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice
U Desai, EC Lee, K Chung, C Gao, J Gay, B Key, G Hansen, ...
Proceedings of the National Academy of Sciences 104 (28), 11766-11771, 2007
2152007
LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)–mediated absorption of intestinal glucose
DR Powell, M Smith, J Greer, A Harris, S Zhao, C DaCosta, F Mseeh, ...
Journal of Pharmacology and Experimental Therapeutics 345 (2), 250-259, 2013
2012013
Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4
LF Drager, Q Yao, KL Hernandez, MK Shin, S Bevans-Fonti, J Gay, ...
American journal of respiratory and critical care medicine 188 (2), 240-248, 2013
1942013
Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t (11; 22) chromosomal translocation. A potential autocrine growth factor.
D Yee, RE Favoni, GS Lebovic, F Lombana, DR Powell, CP Reynolds, ...
The Journal of clinical investigation 86 (6), 1806-1814, 1990
1911990
Structural and biological characterization of bovine insulin-like growth factor binding protein-3
CA Conover, M Ronk, F Lombana, DR Powell
Endocrinology 127 (6), 2795-2803, 1990
1901990
Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract
Q Liu, Q Yang, W Sun, P Vogel, W Heydorn, XQ Yu, Z Hu, W Yu, B Jonas, ...
Journal of Pharmacology and Experimental Therapeutics 325 (1), 47-55, 2008
1892008
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