Nicholas Lamson
Nicholas Lamson
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Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
NG Lamson, A Berger, KC Fein, KA Whitehead
Nature biomedical engineering 4 (1), 84-96, 2020
A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo
KA Hajj, JR Melamed, N Chaudhary, NG Lamson, RL Ball, SS Yerneni, ...
Nano letters 20 (7), 5167-5175, 2020
Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery
N Boehnke, JP Straehla, HC Safford, M Kocak, MG Rees, M Ronan, ...
Science 377 (6604), eabm5551, 2022
Expanding the utility of the dextran sulfate sodium (DSS) mouse model to induce a clinically relevant loss of intestinal barrier function
KE Cochran, NG Lamson, KA Whitehead
PeerJ 8, e8681, 2020
The pH of piperazine derivative solutions predicts their utility as transepithelial permeation enhancers
NG Lamson, G Cusimano, K Suri, A Zhang, KA Whitehead
Molecular Pharmaceutics 13 (2), 578-585, 2016
Structure-function analysis of phenylpiperazine derivatives as intestinal permeation enhancers
KC Fein, NG Lamson, KA Whitehead
Pharmaceutical Research 34, 1320-1329, 2017
Reversible inhibition of efflux transporters by hydrogel microdevices
ES Levy, KE Samy, NG Lamson, KA Whitehead, DL Kroetz, TA Desai
European Journal of Pharmaceutics and Biopharmaceutics 145, 76-84, 2019
Thrifty, rapid intestinal monolayers (TRIM) using caco-2 epithelial cells for oral drug delivery experiments
NG Lamson, RL Ball, KC Fein, KA Whitehead
Pharmaceutical research 36, 1-12, 2019
The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery
NG Lamson, KC Fein, JP Gleeson, AN Newby, S Xian, K Cochran, ...
Proceedings of the National Academy of Sciences 119 (33), e2207829119, 2022
Piperazine derivatives enhance epithelial cell monolayer permeability by increased cell force generation and loss of cadherin structures
S Zheng, K Lavrenyuk, NG Lamson, KC Fein, KA Whitehead, KN Dahl
ACS Biomaterials Science & Engineering 6 (1), 367-374, 2019
Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice
KC Fein, JP Gleeson, K Cochran, NG Lamson, R Doerfler, JR Melamed, ...
Bioengineering & Translational Medicine 8 (1), e10342, 2023
Massively parallel pooled screening reveals genomic determinants of nanoparticle-cell interactions
N Boehnke, JP Straehla, HC Safford, M Kocak, MG Rees, M Ronan, ...
BioRXiv, 2021.04. 05.438521, 2021
From farm to pharmacy: strawberry-enabled oral delivery of protein drugs
NG Lamson, KC Fein, JP Gleeson, S Xian, A Newby, N Chaudhary, ...
bioRxiv, 2020.03. 11.987461, 2020
Method of increasing epithelial permeability using nanoparticles
KA Whitehead, NG Lamson
US Patent App. 16/630,219, 2020
Layer-by-Layer Polymer Functionalization Improves Nanoparticle Penetration and Glioblastoma Targeting in the Brain
AJ Pickering, NG Lamson, MH Marand, W Hwang, JP Straehla, ...
ACS nano 17 (23), 24154-24169, 2023
Core material and surface chemistry of Layer-by-Layer (LbL) nanoparticles independently direct uptake, transport, and trafficking in preclinical blood-brain barrier (BBB) models
NG Lamson, AJ Pickering, J Wyckoff, P Ganesh, JP Straehla, ...
bioRxiv, 2022.10. 31.514595, 2022
Compositions and Methods for Modulating Permeability of Biological Barriers
KA Whitehead, NG Lamson
US Patent App. 17/047,772, 2021
Trafficking through the blood–brain barrier is directed by core and outer surface components of layer‐by‐layer nanoparticles
NG Lamson, AJ Pickering, J Wyckoff, P Ganesh, EA Calle, JP Straehla, ...
Bioengineering & Translational Medicine, e10636, 2023
Bending the Drug Delivery Paradigm By Targeting Nanocarriers for Accumulation within the Body’s Intrinsic Barriers
N Lamson
2022 AIChE Annual Meeting, 2022
Leveraging Immortalized Brain Endothelial Cells to Enable High-Throughput, Preclinical Screening of Nanomaterials for Drug Delivery across the Blood Brain Barrier.
N Lamson, A Pickering, PT Hammond
2021 AIChE Annual Meeting, 2021
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