Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein XJ Sun, P Rothenberg, CR Kahn, JM Backer, E Araki, PA Wilden, ... Nature 352 (6330), 73-77, 1991 | 2042 | 1991 |
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein XJ Sun, P Rothenberg, CR Kahn, JM Backer, E Araki, PA Wilden, ... Nature 352 (6330), 73-77, 1991 | 2042 | 1991 |
Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation. JM Backer, MG Myers Jr, SE Shoelson, DJ Chin, XJ Sun, M Miralpeix, ... The EMBO journal 11 (9), 3469-3479, 1992 | 1257 | 1992 |
Role of IRS-2 in insulin and cytokine signalling XJ Sun, LM Wang, Y Zhang, L Yenush, MG Myers Jr, E Glasheen, ... Nature 377 (6545), 173-177, 1995 | 1167 | 1995 |
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. MG Myers Jr, JM Backer, XJ Sun, S Shoelson, P Hu, J Schlessinger, ... Proceedings of the National Academy of Sciences 89 (21), 10350-10354, 1992 | 664 | 1992 |
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1 XJ Sun, DL Crimmins, MG Myers Jr, M Miralpeix, MF White Molecular and cellular biology 13 (12), 7418-7428, 1993 | 631 | 1993 |
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein L He, A Sabet, S Djedjos, R Miller, X Sun, MA Hussain, S Radovick, ... Cell 137 (4), 635-646, 2009 | 602 | 2009 |
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient-and obesity-induced insulin resistance F Tremblay, S Brûlé, S Hee Um, Y Li, K Masuda, M Roden, XJ Sun, ... Proceedings of the National Academy of Sciences 104 (35), 14056-14061, 2007 | 539 | 2007 |
Cross-talk between the insulin and angiotensin signaling systems. LA Velloso, F Folli, XJ Sun, MF White, MJ Saad, CR Kahn Proceedings of the National Academy of Sciences 93 (22), 12490-12495, 1996 | 488 | 1996 |
IRS-1: essential for insulin-and IL-4-stimulated mitogenesis in hematopoietic cells LM Wang, MG Myers Jr, XJ Sun, SA Aaronson, M White, JH Pierce Science 261 (5128), 1591-1594, 1993 | 483 | 1993 |
IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase MG Myers Jr, XJ Sun, B Cheatham, BR Jachna, EM Glasheen, JM Backer, ... Endocrinology 132 (4), 1421-1430, 1993 | 428 | 1993 |
Protein kinase C θ inhibits insulin signaling by phosphorylating IRS1 at Ser1101 Y Li, TJ Soos, X Li, J Wu, M DeGennaro, X Sun, DR Littman, MJ Birnbaum, ... Journal of Biological Chemistry 279 (44), 45304-45307, 2004 | 426 | 2004 |
Expression and function of IRS-1 in insulin signal transmission. XJ Sun, M Miralpeix, MG Myers, EM Glasheen, JM Backer, CR Kahn, ... Journal of Biological Chemistry 267 (31), 22662-22672, 1992 | 422 | 1992 |
The IRS-1 signaling system MG Myers Jr, XJ Sun, MF White Trends in biochemical sciences 19 (7), 289-293, 1994 | 415 | 1994 |
The Structure and Function of P55PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase S Pons, T Asano, E Glasheen, M Miralpeix, Y Zhang, TL Fisher, ... Molecular and cellular biology 15 (8), 4453-4465, 1995 | 327 | 1995 |
Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. MG Myers, TC Grammer, LM Wang, XJ Sun, JH Pierce, J Blenis, MF White Journal of Biological Chemistry 269 (46), 28783-28789, 1994 | 316 | 1994 |
4ps/insulin receptor substrate (irs)-2 is the alternative substrate of the insulin receptor in irs-1-deficient mice (∗) ME Patti, XJ Sun, JC Bruening, E Araki, MA Lipes, MF White, CR Kahn Journal of Biological Chemistry 270 (42), 24670-24673, 1995 | 301 | 1995 |
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1 R Zhande, JJ Mitchell, J Wu, XJ Sun Molecular and cellular biology 22 (4), 1016-1026, 2002 | 299 | 2002 |
Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins KE Wong, FL Szeto, W Zhang, H Ye, J Kong, Z Zhang, XJ Sun, YC Li American journal of physiology-endocrinology and metabolism 296 (4), E820-E828, 2009 | 295 | 2009 |
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway. XJ Sun, JL Goldberg, LY Qiao, JJ Mitchell Diabetes 48 (7), 1359-1364, 1999 | 282 | 1999 |