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Lok Hei Chan
Lok Hei Chan
Postdoctoral Associate, Yale University
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Hedgehog signaling induces osteosarcoma development through Yap1 and H19 overexpression
LH Chan, W Wang, W Yeung, Y Deng, P Yuan, KK Mak
Oncogene 33 (40), 4857, 2014
1712014
CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation
TL Wong, KY Ng, K Vin Tan, LH Chan, L Zhou, N Che, R LC Hoo, TK Lee, ...
Hepatology, 2019
872019
PRMT6 Regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation
LH Chan, L Zhou, KY Ng, TL Wong, TK Lee, R Sharma, JH Loong, ...
Cell reports 25 (3), 690-701. e8, 2018
822018
Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation
LH CHAN, L Zhou, KY Ng, TL Wong, TK Lee, R Sharma, HC LOONG, ...
Cell Reports, 2018
82*2018
TP53INP1 downregulation activates a p73-dependent DUSP10/ERK signaling pathway to promote metastasis of hepatocellular carcinoma
KY Ng, LH Chan, S Chai, M Tong, XY Guan, NP Lee, Y Yuan, D Xie, ...
Cancer research 77 (17), 4602-4612, 2017
462017
Turning hepatic cancer stem cells inside out–a deeper understanding through multiple perspectives
LH Chan, ST Luk, S Ma
Molecules and cells 38 (3), 202, 2015
452015
The tumor suppressive role of PRMT6 in regulating the pathogenesis of hepatocellular carcinoma
LH Chan, KY Ng, S Ma
Cancer Research 75 (15 Supplement), 2333-2333, 2015
12015
Down-regulation of PRMT6 drives Warburg effect through ERK induced relocalization of PKM2 to promote tumorigenicity and sorafenib resistance in hepatocellular carcinoma
TL Wong, LH Chan, S Ma
Cancer Research 79 (13 Supplement), 1852-1852, 2019
2019
Protein arginine methyltransferase PRMT6 regulates cancer stemness through CRAF methylation in hepatocellular carcinoma
LH Chan, L Zhou, KY Ng, TL Wong, TK Lee, YP Ching, YF Yuan, D Xie, ...
Cancer Research 78 (13 Supplement), 4479-4479, 2018
2018
Abstract LB-139: PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer
LH Chan, L Zhou, KY Ng, TL Wong, S Chai, TK Lee, XY Guan, YP Ching, ...
Cancer Research 77 (13 Supplement), LB-139-LB-139, 2017
2017
Downregulation of PRMT6 promotes the Warburg effect in hepatocellular carcinoma via PKM2
TL Wong, LH Chan, S Ma
Cancer Research 77 (13 Supplement), 5416-5416, 2017
2017
TP53INP1 negatively regulates ERK1/2 via p73-dependent DUSP10 expression to promote metastasis in hepatocellular carcinoma
KY Ng, LH Chan, S Chai, M Tong, XY Guan, NP Lee, YF Yuan, D Xie, ...
Cancer Research 77 (13 Supplement), 4842-4842, 2017
2017
Functional and mechanistic characterization of PRMT6 in regulating the diverse cellular properties implicated in the pathogenesis of hepatocellular carcinoma
L Chan
HKU Theses Online (HKUTO), 2016
2016
The Roles of Hedgehog Signaling in the Development of Osteosarcoma
LH Chan
Chinese University of Hong Kong, 2012
2012
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학술자료 1–14