| A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore BA Krantz, RA Melnyk, S Zhang, SJ Juris, DB Lacy, Z Wu, A Finkelstein, ... Science 309 (5735), 777-781, 2005 | 336 | 2005 |
| Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation DB Lacy, DJ Wigelsworth, RA Melnyk, SC Harrison, RJ Collier Proceedings of the National Academy of Sciences 101 (36), 13147-13151, 2004 | 288 | 2004 |
| Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms P Baker, PJ Hill, BD Snarr, N Alnabelseya, MJ Pestrak, MJ Lee, ... Science advances 2 (5), e1501632, 2016 | 280 | 2016 |
| The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication RA Melnyk, S Kim, AR Curran, DM Engelman, JU Bowie, CM Deber Journal of Biological Chemistry 279 (16), 16591-16597, 2004 | 145 | 2004 |
| Polar residue tagging of transmembrane peptides RA Melnyk, AW Partridge, J Yip, Y Wu, NK Goto, CM Deber Peptide Science 71 (6), 675-685, 2003 | 110 | 2003 |
| A rapid method for the determination of vitamin E forms in tissues and diet by high‐performance liquid chromatography using a normal‐phase diol column JKG Kramer, L Blais, RC Fouchard, RA Melnyk, KMR Kallury Lipids 32 (3), 323-330, 1997 | 110 | 1997 |
| Sequence context strongly modulates association of polar residues in transmembrane helices JP Dawson, RA Melnyk, CM Deber, DM Engelman Journal of molecular biology 331 (1), 255-262, 2003 | 107 | 2003 |
| Retention of native-like oligomerization states in transmembrane segment peptides: application to the Escherichia coli aspartate receptor RA Melnyk, AW Partridge, CM Deber Biochemistry 40 (37), 11106-11113, 2001 | 106 | 2001 |
| Crystal structure of Clostridium difficile toxin A NM Chumbler, SA Rutherford, Z Zhang, MA Farrow, JP Lisher, E Farquhar, ... Nature microbiology 1 (1), 1-6, 2016 | 102 | 2016 |
| Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants PM Gorman, S Kim, M Guo, RA Melnyk, J McLaurin, PE Fraser, JU Bowie, ... BMC neuroscience 9, 1-11, 2008 | 98 | 2008 |
| Transmembrane domain mediated self-assembly of major coat protein subunits from Ff bacteriophage RA Melnyk, AW Partridge, CM Deber Journal of molecular biology 315 (1), 63-72, 2002 | 81 | 2002 |
| bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA) S Lim, R Khoo, KM Peh, J Teo, SC Chang, S Ng, GL Beilhartz, RA Melnyk, ... Proceedings of the National Academy of Sciences 117 (11), 5791-5800, 2020 | 79 | 2020 |
| Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore Z Zhang, M Park, J Tam, A Auger, GL Beilhartz, DB Lacy, RA Melnyk Proceedings of the National Academy of Sciences 111 (10), 3721-3726, 2014 | 77 | 2014 |
| A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation RA Melnyk, RJ Collier Proceedings of the National Academy of Sciences 103 (26), 9802-9807, 2006 | 77 | 2006 |
| A model of anthrax toxin lethal factor bound to protective antigen DB Lacy, HC Lin, RA Melnyk, O Schueler-Furman, L Reither, ... Proceedings of the National Academy of Sciences 102 (45), 16409-16414, 2005 | 76 | 2005 |
| Polar residues in membrane domains of proteins: Molecular basis for helix− helix association in a mutant CFTR transmembrane segment AW Partridge, RA Melnyk, CM Deber Biochemistry 41 (11), 3647-3653, 2002 | 71 | 2002 |
| Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage J Tam, GL Beilhartz, A Auger, P Gupta, AG Therien, RA Melnyk Chemistry & biology 22 (2), 175-185, 2015 | 70 | 2015 |
| Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin J Tam, S Icho, E Utama, KE Orrell, RF Gómez-Biagi, CM Theriot, HK Kroh, ... Proceedings of the National Academy of Sciences 117 (12), 6792-6800, 2020 | 63 | 2020 |
| Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants P Gupta, Z Zhang, SN Sugiman-Marangos, J Tam, S Raman, JP Julien, ... Journal of Biological Chemistry 292 (42), 17290-17301, 2017 | 59 | 2017 |
| Efficient delivery of structurally diverse protein cargo into mammalian cells by a bacterial toxin A Auger, M Park, F Nitschke, LM Minassian, GL Beilhartz, BA Minassian, ... Molecular pharmaceutics 12 (8), 2962-2971, 2015 | 59 | 2015 |
